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Merck KGaA
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14 February 2012
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A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.
| Product information | |||
|---|---|---|---|
| Form | Light brown lyophilized solid | ||
| Primary Target | PKC | ||
| Primary Target IC50 | 50 nM | ||
| Secondary target | mlck (IC50 = 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM) | ||
| Molar mass | 790.8 | ||
| Protect from Light | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C44H38O14 | ||
| CAS number | 121263-19-2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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