Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
| Product information | |||
|---|---|---|---|
| Form | White to off-white solid | ||
| Hygrocopic | Yes | ||
| Biological activity | Potency: 1.5-2.0 U/mg | ||
| Purity | ≥90% by HPLC (A2 + B2) | ||
| Solubility | H2O | ||
| RTECS | EC5991990 | ||
| CAS number | 9041-93-4 | ||
| Merck USA index | 14, 1318 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic |
||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
||
| R Phrase |
R: 20/21/22-36/37/38-40-42/43 Limited evidence of a carcinogenic effect. |
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