203290
Bisindolylmaleimide I
2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, GF 109203X, Gö 6850
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14 February 2012
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A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα-, βI-, βII-, γ-, δ-, and ε- isozymes. Potently inhibits GSK-3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK-3β immunoprecipitates (IC50 = 170 nM). May inhibit protein kinase A at a much higher concentration (IC50 = 2 µM). A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203293) in anhydrous DMSO is also available.
| Product information | |||
|---|---|---|---|
| Form | Deep orange solid | ||
| Primary Target | PKC | ||
| Secondary target | GSK-3 (IC50 = 360 nM), GSK-3β (IC50 = 170 nM), PKA (Ki = 2 mM) | ||
| Molar mass | 412.5 | ||
| Protect from Light | Yes | ||
| Cell permeable | Yes | ||
| Reversible | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C25H24N4O2 | ||
| CAS number | 133052-90-1 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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