Anti-neoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. At higher concentrations, DNA polymerase is inhibited. Also acts as a competitive inhibitor of serine proteases. Inhibits cell growth and colony formation in synchronized HeLa cells. Induces apoptosis in many cell lines. However, actinomycin D has also been shown to suppress etoposide-induced apoptosis in PC12 cells. Note: 1 set = 20 x 200 µg.
Stability: heat resistant and stable between pH 2 and 11. Decomposed by strong acids and bases.
| Product information | |||
|---|---|---|---|
| Form | Red crystalline solid | ||
| Primary Target | serine proteases | ||
| Secondary target | cell growth and colony formation in synchronized HeLa cells | ||
| Molar mass | 1255.5 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO, MeOH, or CHCl3 | ||
| Chemical formula | C62H86N12O16 | ||
| RTECS | AU1575000 | ||
| CAS number | 50-76-0 | ||
| Merck USA index | 14, 2800 | ||
| Store and ship information | |||
|---|---|---|---|
|
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
|||
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic & Carcinogenic / Teratogenic |
||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 28-36/37-45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
||
| R Phrase |
R: 28 Very toxic if swallowed. |
||
