Stem Cell Resource

Introduction to Pluripotent Stem Cells

By Karl Willert, Ph.D., Director UCSD Stem Cell Core

The derivation of the first human embryonic stem cells (hESCs) by Dr. James Thomson in 1998 (Thomson et al., 1998) ushered in a new era in biomedical research and opened the door to novel therapeutic treatments of previously incurable diseases. From a strictly scientific perspective, hESCs represent a unique and powerful model system to study human development at the cellular level. Read more…

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News and Views
July 8, 2009: Human Sperm Created From Embryonic Stem Cells February 4, 2009: Stem Cell Breakthrough in Japan January 23, 2009: FDA Approves a Stem Cell Trial December 18, 2008: FDA Approves Drug That Boosts Stem Cell Yield for Bone Marrow Transplants December 10, 2007: Scientists Discover Factor That Controls Fate Of Dopamine Neurons June 27, 2007: Stem cells may speed race for cures

Information Resources
NIH Stem cell Information International Society for Stem Cell Research Harvard Stem Cell Institute Stem Cell Research News The Stem Cell Database

Research Articles
Maherali N and Hochedlinger K. (2009) Tgfb Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc. Current Biology 19, 1-6. Ichida J, et al. (2009) A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog. Cell Stem Cell 5, 1-13. Li W and Ding S. (2009) Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends in Pharm Sci. Published Online [DOI:10.1016/j.tips.2009.10.002] Zhou H, et al. (2009) Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins. Cell Stem Cell. 4(4), 381-384. Feng B, et. al. (2009) Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells. Cell Stem Cell. 4(4), 301-312. Nishikawa S, et. al. (2008) The promise of human induced pluripotent stem cells for research and therapy. Nat Rev Mol Cell Biol. 9(9), 725-9. Huangfu D, et. al. (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature Biotechnology. 26(11), 1269-75. Ying QL, et. al. (2008) The ground state of embryonic stem cell self-renewal. Nature. 453(7194), 519-23. Masato Nakagawa, et al. (2007) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nature Biotechnology. Published online. [DOI: 10.1038/nbt1374] Watanabe K, et al. (2007) A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnology. 25(6) Thompson CC, et al. (2006) Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation. Cell Cycle. 5(17) Even-Ram S, et al. (2006) Matrix control of stem cell fate. Cell. 126. 645-7.

Research Articles

Maherali N and Hochedlinger K. (2009) Tgfb Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc. Current Biology 19, 1-6.
Ichida J, et al. (2009) A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog. Cell Stem Cell 5, 1-13.
Li W and Ding S. (2009) Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends in Pharm Sci. Published Online [DOI:10.1016/j.tips.2009.10.002]
Zhou H, et al. (2009) Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins. Cell Stem Cell. 4(4), 381-384.
Feng B, et. al. (2009) Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells. Cell Stem Cell. 4(4), 301-312.
Nishikawa S, et. al. (2008) The promise of human induced pluripotent stem cells for research and therapy. Nat Rev Mol Cell Biol. 9(9), 725-9.
Huangfu D, et. al. (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature Biotechnology. 26(11), 1269-75.
Ying QL, et. al. (2008) The ground state of embryonic stem cell self-renewal. Nature. 453(7194), 519-23.
Masato Nakagawa, et al. (2007) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nature Biotechnology. Published online. [DOI: 10.1038/nbt1374]
Watanabe K, et al. (2007) A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnology. 25(6)
Thompson CC, et al. (2006) Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation. Cell Cycle. 5(17)
Even-Ram S, et al. (2006) Matrix control of stem cell fate. Cell. 126. 645-7.