616454
TGF-β RI Kinase Inhibitor IV
Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
11 Fevereiro 2012
carregando
| Nº de produto | Tamanho |
|---|---|
| 616454-2MG | 2 mg |
A cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | Pale yellow solid | ||
| Protect from Light | Sim | ||
| Packaged under inert gas | Sim | ||
| Purity | ≥97% by HPLC | ||
| Fórmula Química | C25H19N5S | ||
| Número CAS | 909910-43-6 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful |
||
