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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
13 Fevereiro 2012
carregando
| Nº de produto | Tamanho |
|---|---|
| 567630-5GM | 5 gm |
A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases | ||
| Secondary target | TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-kB activation. | ||
| Hygrocopic | Sim | ||
| Packaged under inert gas | Sim | ||
| Cell permeable | Sim | ||
| Purity | ≥98% by titration | ||
| Fórmula Química | C7H5O3 · Na | ||
| RTECS | VO5075000 | ||
| Número CAS | 54-21-7 | ||
| Merck USA index | 14, 8332 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Harmful |
||
| Informações de segurança | |||
|---|---|---|---|
| Frases S |
S: 24/25 |
||
| Frases R |
R: 22 |
||
