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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
13 Fevereiro 2012
carregando
| Nº de produto | Tamanho |
|---|---|
| 554325-25MG | 25 mg |
A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | COX-1 | ||
| Primary Target IC50 | ED50 = 15 µM | ||
| Secondary target | hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM), insoluble transthyretin (TTR) amyloid fibril formation, phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM), acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA.,inhibitor of P450 1A1 | ||
| Protect from Light | Sim | ||
| Packaged under inert gas | Sim | ||
| Purity | ≥98% by TLC | ||
| Fórmula Química | C14H12O3 | ||
| Número CAS | 501-36-0 | ||
| Merck USA index | 14, 8158 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
