405268
Indomethacin
1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
Para informações, por favor, contate o nosso Serviço de Atendimento ao Cliente
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
13 Fevereiro 2012
carregando
| Nº de produto | Tamanho |
|---|---|
| 405268-10GM | 10 gm |
A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | White to off-white powder | ||
| Primary Target | COX-1 | ||
| Primary Target IC50 | 740 nM | ||
| Secondary target | COX-2 (IC50 = 970 nM), A2 (IC50 = 145 µM) | ||
| Cell permeable | Sim | ||
| Purity | ≥98% by assay | ||
| Fórmula Química | C19H16ClNO4 | ||
| RTECS | NL3500000 | ||
| Número CAS | 53-86-1 | ||
| Merck USA index | 14, 4968 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Armazenagem | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic & Carcinogenic / Teratogenic |
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| Informações de segurança | |||
|---|---|---|---|
| Frases S |
S: 36/37/39-45 |
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| Frases R |
R: 28-42/43-63 |
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