344555
FTI-277
Methyl {N-[2-phenyl-4-N [2(R)-amino-3-mecaptopropylamino] benzoyl]}-methionate, TFA
Para informações, por favor, contate o nosso Serviço de Atendimento ao Cliente
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
13 Fevereiro 2012
carregando
| Nº de produto | Tamanho |
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This product has been discontinued.
Please refer to our complete listing of farnesyltransferase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.Prodrug form of FTI-276 (Cat. No. 344550) that acts as a highly potent and selective inhibitor of FTase (IC50 = 50 nM). Inhibits H-Ras processing in whole cells (IC50 = 100 nM), but it does not inhibit geranylgeranylated Rap1A processing even at 10 µM. Induces accumulation of non-farnesylated cytoplasmic H-Ras, which binds to Raf protein to form inactive Ras/Raf complexes. FTI-277 is also highly effective and selective in disrupting constitutive H-Ras-specific activation of MAP kinase. Induces apoptosis in v-K-ras-transformed normal rat kidney (KNRK) cells, but not in control NRK cells.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | Colorless to white semi-solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | FTase | ||
| Primary Target IC50 | 50 nM | ||
| Secondary target | H-Ras (IC50 = 100 nM) | ||
| Hygrocopic | Sim | ||
| Packaged under inert gas | Sim | ||
| Purity | ≥95% by HPLC | ||
| Fórmula Química | C22H29N3O3S2 | ||
| Número CAS | 170006-73-2 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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