344550
FTI-276
N-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
13 Fevereiro 2012
carregando
| Nº de produto | Tamanho |
|---|---|
| 344550-250UG | 250 μg |
A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | White solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | FTase in vitro | ||
| Primary Target IC50 | 500 pM | ||
| Secondary target | GGTase 1 (IC50 = 50 nM) | ||
| Hygrocopic | Sim | ||
| Packaged under inert gas | Sim | ||
| Purity | ≥90% by HPLC | ||
| Fórmula Química | C21H27N3O3S2 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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