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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
13 Fevereiro 2012
carregando
| Nº de produto | Tamanho |
|---|---|
| 401003-1GM | 1 gm |
A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC50 = 4.85 µM). Inhibits COX-2 at higher concentrations (IC50 = 223 µM). Blocks aspirin inactivation of COX-1 (EC50 antagonism of 200 µM aspirin = 290 nM). Shown to reduce the total Aβ secretion (Amyloid β40 and 42) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage. Reported to activate peroxisome proliferator-activated receptors (PPAR) α and γ in both CV-1 and C3H10T1/2 cells (~100 µM-500 µM).
| Informações sobre o produto | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | COX-1 | ||
| Primary Target IC50 | IC50 = 4.85 mM | ||
| Secondary target | COX-2 (IC50 = 223 mM) | ||
| Protect from Light | Sim | ||
| Reversible | Sim | ||
| Purity | ≥98% by titration | ||
| Fórmula Química | C13H18O2 | ||
| RTECS | MU6640000 | ||
| Número CAS | 15687-27-1 | ||
| Merck USA index | 14, 4881 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Harmful |
||
| Informações de segurança | |||
|---|---|---|---|
| Frases S |
S: 36 |
||
| Frases R |
R: 22 |
||
